Parizvino, kune marudzi makumi masere nerimwe emishonga inorwisa bundu inowanzoshandiswa mukiriniki.1. Anti-bundu mishonga inorongwa maererano nekwavo uye nzira yekuita.Kazhinji yakakamurwa kuva alkylating zvinodhaka, antimetabolites, mishonga inorwisa mabhakitiriya, zvirimwa, mahormone uye mamwe madhiragi.Mimwe mishonga inosanganisira platinum, asparaginase, yakanangwa kurapa mishonga, nezvimwewo, kusasanganisa biological reagents uye gene therapy.Iyi kupatsanurwa haigone kupfupisa kuvandudzwa kwazvino kwemishonga inorwisa bundu.Chechipiri, imwe kupatsanurwa kwakavakirwa pamamolecular tarisiro emishonga, iyo yakakamurwa muzvikamu zvakawanda.Chikamu chekutanga mishonga inoshanda pamakemikari eDNA, akadai sealkylating kana platinum compounds.Chikamu chechipiri zvinodhaka zvinokanganisa nucleic acid synthesis, zvakadai se antimetabolites.Chikamu chechitatu ndiwo mushonga unoshanda pane template yeDNA, unokanganisa kunyorwa uye kuvharirwa kweDNA, uye inhibits RNA synthesis nekuvimba neRNA polymerase.Chikamu chechina mishonga inobata protein synthesis, yakadai sepaclitaxel, vinblastine nezvimwe zvakadaro.Chikamu chekupedzisira nderimwe mhando dzemishonga, senge mahormone, aspartic acid, yakanangwa kurapa mishonga, nezvimwewo, asi ikozvino anti-bundu mishonga iri kukura nekukurumidza, uye mapoka ari pamusoro haakwanise kupfupisa mishonga iripo uye mishonga iri pamusoro. kupinda mukiriniki..“

Parizvino, kune akawanda anti-tumor zvinodhaka mumakiriniki maitiro.Semuyenzaniso,oxaliplatin, fluorouracil, uye irinotecan inogona kushandiswa pamakumbo emudumbu.Varwere vane gomarara remudumbu vanogona kurapwa nemishonga yakadaicisplatinuyepaclitaxel.Kazhinji, kenza dzakasiyana dzinosarudza mishonga yakasiyana.Pamusoro pezvo, varwere vegomarara vanogonawo kurapwa nemishonga inonangwa nemakemikari, senge erlotinib, osimertinib, cetuximab nemimwe mishonga.

Zvakajairwa anti-tumor mishonga inokonzera CIPN inosanganisiraPaclitaxel, Platinum, Vinblastine,Methotrexate, Fluorouracil, Ifosfamide,Cytarabine, Fludarabine, Thalidomide,Bortimiazolezvichingoenda zvakadaro.

Paclitaxel inoshandisa nerve kukura chinhu kuderedza kana kudzosera kumashure neurotoxicity;cisplatin inoshandisa yakaderedzwa glutathione uye amifostine kudzivirira neuropathy inokonzerwa nazvo;oxaliplatin haibatanidzi inotonhora kukurudzira panguva yekushandiswa kudzivirira kutonhora kukurudzira kubva pakukanganisa peripheral nerves Kukurudzira, kushandiswa kwecalcium-magnesium musanganiswa kunogona kuderedza chiitiko uye kusimba kweacute neurotoxicity zviratidzo, uye kunonoka kuitika kwe cumulative neuropathy;ifosfamide inogona kusarudza methylene yebhuruu kudzivirira neurotoxicity;shandisa thiamine ye fluorouracil inogona kudzivirira tsinga Toxic effect.